Scream V marked a major transition for the franchise, introducing a cast of new characters while legacy protagonists like Gale Weathers, Deputy Dewey, and Sidney Prescott were relegated to supporting roles or killed off. This set up Scream VI to mostly stand on its own while building off of the franchise's legacy, emphasizing how much directors Matt Betinelli-Olpin and Tyler Gillett love Scream and the horror genre.
from CBR